The Fox System: A Novel, Laser-Free FPOP Footprinting Platform
ABSTRACT
Dr. Sharp discusses a covalent labeling technique called fast photochemical oxidation of proteins (FPOP), detailing the workflow, its application in research, and how a new platform is designed to enhance user-friendliness. The Fox Oxidation System streamlines the entire process, from radical generation to sample collection, improving safety, reliability, and ease of use compared to traditional FPOP setups. This innovation makes HRPF accessible to more researchers, allowing them to gain valuable insights into protein structures and interactions with greater ease.
SPEAKER
Dr. Joshua Sharp is an internationally recognized expert in HRPF, pioneering novel MS-based technology to study HOS focusing on the structure-function relationships of proteins and carbohydrates. With more than 21 peer-reviewed articles, Dr. Sharp has also presented numerous invited lectures around the world. Along with acting as the Chief Technology Officer of GenNext, Dr. Sharp is also Associate Professor of Pharmacology, Associate Professor of Chemistry and Biochemistry, and Director of the Glycoscience Center of Research Excellence at the University of Mississippi.
