Flash Oxidation (Fox^®) Hydroxyl Radical Protein Footprinting for mAb Aggregation

Presented by Dr. Emily Chea of GenNext Technologies

Spend less than 10 minutes with Dr. Chea as she explains how the Flash Oxidation (Fox) Protein Footprinting System can characterize monoclonal antibody (mAb) aggregation and determine how excipients help stabilize the protein. Excipients, like amino acids, can stabilize proteins and limit aggregation. By comparing the change in hydroxyl radical modification before and after the addition of an amino acid, you can detect intermolecular interactions that take place during mAb aggregation. By better understanding the higher order structure of protein aggregation, you will be armed with the information you need to optimize mAb formulation and development.