Educational Materials on Advanced Fox-Based HRPF
Literature on the Application of HRPF
POSTER NOTE
Demonstration of Adalimumab Structural Stability in Various pHs using High Throughput HRPF with the AutoFox® Protein Footprinting System
These findings provide valuable insights into the stability and conformational dynamics of Adalimumab under different pH conditions.
POSTER NOTE
Streamline Mass Spec-Based Structural Biology Experiments with the High-Throughput AutoFox® Protein Footprinting System
The AutoFox System provides accurate measurements of solvent accessibility, as indicated by strong correlations between the calculated protection factors (PF) and known crystal structure solvent accessibility (SASA).
POSTER NOTE
Automated Hydroxyl Radical Protein Footprinting in a 96-Well Format
First-in-class instrument for fully automated protein footprinting demonstrates highly precise and accurate quantification for numerous higher order structure (HOS) mapping experiments.
POSTER NOTE
Improving TNFα’s Epitope Identification with Residue Level HRPF using the ZenoTOF 7600 system
Powerful MS/MS sensitivity and enhanced ion fragmentation technology allows for localization of challenging PTMs and more comprehensive understanding of protein structure.
POSTER NOTE
Characterizing Glycan-Induced Structural Changes and Binding Interfaces for IgG1-C1q Complex using HRPF
HRPF identifies a binding pocket of IgG1 with C1Q with improved resolution using residues level analysis.
WHITE PAPER
Revealing Antibody Aggregation with Fox® Protein Footprinting Technology
Understanding protein-protein interactions so researchers can develop high concentration biotherapeutics.
POSTER NOTE
Improved Methods for Residue-Level Mass Spectrometry Data Acquisition and HRPF Data Interpretation
Learn how the inclusion list approach improved MS and low-intensity modified residue identification, along with improving matches by 30 times.
POSTER NOTE
FoxWare® Software Resolves Isomeric Heterogeneity and Retention Time Drift in Oxidized Peptides from HRPF
Learn how FoxWare Software handles key issues with HRPF data analysis, increasing the statistical robustness of quantitation.
POSTER NOTE
Laser-Free Flash Oxidation (Fox®) HRPF System Accurately Maps the Epitope of TNFα Bound to Adalimumab
Learn how Fox-based FPOP detected 4 TNF-α peptides with a significant decrease in oxidation following Ab binding known to be a part of the
TNFα-Ab interface.
POSTER NOTE
Characterizing Type III Kinase Inhibitor Using Laser-Free Flash Oxidation (Fox®) Hydroxyl Radical Protein Footprinting
Learn how the Fox HRPF System conducts In Vitro and In-cell FPOP to deliver a snapshot of the Higher Order Structure of the full proteome.
POSTER NOTE
FoxWare® Protein Footprinting Software Accurately Track Changes in Amino Acid Solvent Accessibility
Learn how FoxWare Software performs automated assignment and relative quantitation of residue-level changes in protein-binding interactions.
POSTER NOTE
In Vitro and In-Cell Radical Dosimetry for Reproducible HRPF Experiments
Learn how the Fox®-based HRPF System conducts In Vitro and In-cell FPOP to deliver a snapshot of the Higher Order Structure of the full proteome.
POSTER NOTE
FoxWare® Protein Footprinting Software — An Integrated Package for HRPF
Learn how FoxWare Software’s Radical Dosimetry, Data Processing, and Data Analysis Modules help you gain actionable insights from your HRPF experiments.
Literature on HRPF Technology, Products, and Services
CO-MARKETING FLYER
Gennext & Agilent Technology Integration
The integration of GenNext’s AutoFox Protein Footprinting System with Agilent’s 6560 Ion Mobility Quadrupole Time-of-Flight (IM-QTOF) LC/MS System presents an unparalleled approach to detailed protein structure analysis and biomolecular interaction studies. T
BROCHURE
The Game-Changing AutoFox® System: Reinventing Protein Higher Order Structural Analysis
Comprised of a user-friendly benchtop instrument coupled with intuitive data analysis software, our second-generation instrument has evolved into a more robust and hands-free tool.
BROCHURE
Fox® Footprinting: The Next Generation of Protein HOS Analysis
Reinventing the study of protein Higher Order Structure (HOS) through automated Hydroxyl Radical Protein Footprinting (HRPF).
TECH NOTE
Review of Technologies for Biopharmaceutical Higher Order Structural (HOS) Analysis
Identifying the most robust and state-of-the-art HOS analytical method for biotherapeutic discovery and development.
SERVICES FAQs
Frequently Asked Questions
Flash Oxidation (Fox) Protein Footprinting Services for Higher Order Structural (HOS) Analysis
Learn about HRPF services from what can be studied, what data can be generated, what samples are required, to starting a service project with GenNext.
PRODUCT & SERVICE NOTE
Revolutionizing Protein Higher Order Structural Analysis
Novel products and services for Hydroxyl Radical Protein Footprinting (HRPF) to accelerate biopharmaceutical/biosimilar development and protein conformational research.
PRODUCT NOTE
Unrivaled Higher Order Structural (HOS) Analysis for Biopharmaceutical Discovery & Development
Learn how your research programs will realize massive savings in time and money, robust and reproducible data generation and analysis, and a much simplified and faster workflow.
SOFTWARE NOTE
FoxWare® Protein Footprinting Software
Introducing new HRPF analysis software—a user-friendly bioinformatics tool for quickly and accurately interpreting results from Fast Photochemical Oxidation of Proteins (FPOP) experiments.
SOFTWARE NOTE
Evaluation of XIC Peaks for Inclusion in Average Peptide Oxidation Calculations
FoxWare Data Processing Software evaluates the XIC peaks to include them when calculating the average peptide oxidation.