Literature on the Application of HRPF

Laser-Free Flash Oxidation (Fox®) HRPF System Accurately Maps the Epitope of TNFα Bound to Adalimumab

Learn how Fox-based FPOP detected 4 TNF-α peptides with a significant decrease in oxidation following Ab binding  known to be a part of the
TNFα-Ab interface.

Characterizing Type III Kinase Inhibitor Using Laser-Free Flash Oxidation (Fox®) Hydroxyl Radical Protein Footprinting

Learn how the Fox HRPF System conducts In Vitro and In-cell FPOP to deliver a snapshot of the Higher Order Structure of the full proteome.

FoxWare^® Protein Footprinting Software Accurately Track Changes in Amino Acid Solvent Accessibility

Learn how FoxWare Software performs automated assignment and relative quantitation of residue-level changes in protein-binding interactions.

In Vitro and In-Cell Radical Dosimetry for Reproducible HRPF Experiments

Learn how the Fox®-based HRPF System conducts In Vitro and In-cell FPOP to deliver a snapshot of the Higher Order Structure of the full proteome.

FoxWare® Protein Footprinting Software — An Integrated Package for HRPF

Learn how FoxWare Software’s Radical Dosimetry, Data Processing, and Data Analysis Modules help you gain actionable insights from your HRPF experiments.

Revealing Antibody Aggregation with Fox® Protein Footprinting Technology

Understanding protein-protein interactions so researchers can develop high concentration biotherapeutics.

Literature on HRPF Technology, Products, and Services

Review of Technologies for Biopharmaceutical Higher Order Structural (HOS) Analysis

Identifying the most robust and state-of-the-art HOS analytical method for biotherapeutic discovery and development.

Frequently Asked Questions
Flash Oxidation (Fox) Protein Footprinting Services for Higher Order Structural (HOS) Analysis

Learn about HRPF services from what can be studied, what data can be generated, what samples are required, to starting a service project with GenNext.

Revolutionizing Protein Higher Order Structural Analysis

Novel products and services for Hydroxyl Radical Protein Footprinting (HRPF) to accelerate biopharmaceutical/biosimilar development and protein conformational research.

Unrivaled Higher Order Structural (HOS) Analysis for Biopharmaceutical Discovery & Development

Learn how your research programs will realize massive savings in time and money, robust and reproducible data generation and analysis, and a much simplified and faster workflow.

FoxWare® Protein Footprinting Software

Introducing new HRPF analysis software—a user-friendly bioinformatics tool for quickly and accurately interpreting results from Fast Photochemical Oxidation of Proteins (FPOP) experiments.

Evaluation of XIC Peaks for Inclusion in Average Peptide Oxidation Calculations

FoxWare Data Processing Software evaluates the XIC peaks to include them when calculating the average peptide oxidation.