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Fox Radical Protein Footprinting Services
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Structural Biology Services
Experimental Structural Evidence for Biotherapeutics, Small Molecules & AI-Driven Drug Discovery
Every successful drug discovery program depends on making confident scientific decisions. Whether developing biotherapeutics, advancing small molecule therapeutics, or evaluating AI-generated drug candidates, researchers need experimental evidence that reduces uncertainty and guides the next critical decision.
GenNext delivers that evidence through our proprietary Fox Radical Protein Footprinting (FRPF) platform. By measuring residue-level structural changes with exceptional sensitivity while requiring only minimal sample quantities, we rapidly answer the structural biology questions that matter most, helping scientists move promising programs forward with greater confidence.
Most Requested Service Projects by Biopharmaceutical Clients
Epitope & Paratope Mapping: Determine precisely where therapeutic antibodies bind and identify the interaction surfaces that drive efficacy, specificity, and mechanism of action.
Biosimilarity Assessment: Compare innovator biologics and biosimilars to identify meaningful structural differences arising from manufacturing, formulation, or process changes.
AI Biotherapeutic Discovery: Experimentally evaluate competing AI-generated structural hypotheses early in discovery, allowing computational predictions to be validated with real-world structural evidence before significant resources are committed.
Learn more about mAb and biotherapeutic applications of Fox Radical Protein Footprinting Technology.
Learn more about GneNext’s Fox radical protein footprinting services in the mAb design and production workflow.
Target Engagement & Response: Confirm that candidate molecules engage their intended targets while revealing how binding changes protein structure and function.
Lead Optimization & Structure-Activity Relationships: Determine whether chemical modifications preserve target engagement and structural response, enabling more informed lead optimization and medicinal chemistry decisions.
The growing application of Fox Technology empowers our biopharmaceutical customers to gain valuable insights throughout the drug pipeline.
Why Biotherapeutic Teams Partner with GenNext
Scientific Confidence. Rapid Answers. Transparent Collaboration.
Drug discovery moves quickly, and every experimental result influences the next decision. GenNext provides high-quality structural biology services designed to answer critical scientific questions rapidly, transparently, and with the scientific rigor required for confident decision-making.
Experimental Evidence You Can’t Get Elsewhere
Our FRPF platform provides residue-level structural information that complements traditional structural biology techniques while delivering answers faster and using significantly less sample than many legacy methods.
Accelerate Scientific Decisions
Receive actionable structural biology data within days to weeks rather than months, enabling faster design-build-test cycles and helping promising therapeutic programs advance with greater confidence.
Scientific Partnership from Start to Finish
Our scientists work directly with your team—from project design through data interpretation—to ensure your experimental objectives remain the focus throughout every stage of the engagement.
GenNext stands apart as your expert partner from discovery to development. Explore the technology advantages and high-value insights available via our Fox services.
Flexible Services for Every Organization
Whether you’re an emerging biotech, established pharmaceutical company, contract research organization, or AI-enabled drug discovery company, GenNext adapts each project to your specific scientific objectives.
Small to Mid-Cap Pharma & Biotechs
Our service partners are innovative biotech and pharmaceutical companies with critical structural biology questions, but they do not have the budget, bandwidth, or timeline for adopting new technology. Outsourcing to GenNext enables these leaders to stay focused on their core competencies while allowing us to add an extra dimension to their understanding of protein structure and interactions.
Large Pharma & Research Institutions
Industry leaders also collaborate with GenNext by “test driving” our services as a first step toward purchasing our state-of-the-art technology. By experiencing our technology firsthand, these organizations can make confident decisions to go forward with capital equipment investments or elect to continue outsourcing to us on a routine basis with multi-project or multi-year agreements.
Research Services Labs
CROs, CDMOs, and Core Labs choose GenNext’s services to expand their scientific offerings in scenarios where building internal protein footprinting expertise is not feasible. When partnering with us, these labs offer their clients access to novel, high-quality structural biology data on an accelerated timeline. This highly strategic move separates them from the competition and opens the door to new levels of service for their clients.
Need expert structural biology support for mission-critical programs?
Require rapid answers to therapeutic target engagement and structural response?
Lack in-house protein footprinting or biological mass spectrometry capabilities?
Want immediate access to specialized expertise without investing in new instrumentation and talent?
Whether you’re a nimble biotech, a mid-sized pharma, an established industry leader, or a service provider, our solutions can be tailored to fit your specific needs.
Our Six-Step Process from Consultation to Answers
Seamless, Flexible & Fast from Start-to-Finish
At GenNext, we can deliver results within days to a few weeks of receiving your samples. Our services are built for agility, whether you need answers for a single study or a comprehensive, extended analytical partnership. You always get the expertise, reliability, and answers you require with our client-focused process.
Our track record speaks for itself—trusted by industry leaders and up-and-coming pioneers alike. When it comes to biotherapeutic and small molecule protein characterization, along with AI model validation, GenNext stands apart as your expert partner from discovery to development.
Explore the Process
Our team qualifies your needs via a brief questionnaire, setting the stage for a successful and efficient collaboration.
We take a deep dive into your scientific questions and assess how our science, technology, and scientists can help get you the answers you need.
Our team then scopes the project by defining deliverables, timeline, and required sample information, ensuring clarity and alignment.
Then you will receive a fully transparent project quotation detailing the specific experiments, deliverables, and payment terms. Once the quote is approved, a Statement of Work (SOW) and contract will be executed.
After we receive your samples and buffers, we begin methods development and proceed to the Fox Radical Protein Footprinting study. Checkpoint meetings occur to review critical results that keep us on track.
Finally, we produce a clear, detailed, and actionable report that informs the next steps in your drug discovery and development process.
Expert Analysis
& Actionable Reporting
More than Just Data—You Get Answers
When you partner with GenNext, you get clear, concise answers to your most pressing structural biology questions. Our final deliverable is a detailed report that includes:
Experimental Design & Methodologies
The report provides a clear summary of how your unique research question was tackled, along with a description of the methods, workflow, and techniques utilized.
Raw & Analyzed Results
According to the research methodology, the report will illustrate protein dose response, sequence coverage, peptide- and residue-level oxidation, and differential study results. Publication- and presentation-worthy figures are included, such as histograms, volcano plots, heatmaps, and protein structure maps (if available). Additionally, you can access the raw data files and the full set of processed tables to perform further analyses and to augment your datasets.
Expert Review of Structural Implications
Whether the location of an epitope or paratope, detailed aggregation profiles, or a direct assessment of drug-target binding, the report provides the answer you seek. At the report presentation meeting, we help interpret the results with your team to understand structural changes, interaction surfaces, and relevant mechanistic insights.
Trusted by Innovators
From small biotechs to global pharmaceutical leaders, our clients trust us for a partnership mindset focused on their success.
✓ Strong track record of quickly delivering high-quality, actionable insights
✓ Proven cutting-edge technology combined with scientific excellence
✓ Flexible, transparent, and seamless partnership model
✓ Expert Scientific Support