Hacking Structural Biology for Drug Discovery Using Mass Spectrometry
ABSTRACT
Mark Chance discussed his vision for proteomics and structural biology, focusing on megadalton protein complexes and the technologies needed to study them. He highlighted the importance of combining techniques like NMR, crystallography, cryo-EM, and mass spectrometry for protein interaction insights. He explained hydroxyl radical footprinting, a method for mapping protein surfaces and how it has advanced drug development. He shared examples from Rodeo Therapeutics, CASMA, and Foghorn Therapeutics, showcasing its practical applications.
SPEAKER
Professor Chance is an internationally recognized expert in proteomics and structural biology who has built multiple science and training programs over a 30-year career in academia. He has published over 300 papers with over 15,000 citations. He is currently Vice Dean for Research and holds the titles of Distinguished University Professor, the Charles W. and Iona A. Mathias Professor of Cancer Research, as well as Professor appointments in the Departments of Nutrition, Genetics & Genome Sciences, and General Medical Sciences at the School of Medicine of Case Western Reserve University (CWRU). He is the founding director (since 2005) of the Center for Proteomics and Bioinformatics and founding director of the Center for Synchrotron Biosciences (since 1994). Prior to his appointment at CWRU, Dr. Chance was professor of Physiology and Biophysics at Albert Einstein College of Medicine.
