MONOCLONAL ANTIBODY TOOLKIT
Virtual Presentations on HOS in mAb Design & Development
Fox® Hydroxyl Radical Protein Footprinting (HRPF) for mAb Drug Development
Fox® Hydroxyl Radical Protein Footprinting (HRPF) for mAb Aggregation
Fox® Protein Footprinting System Maps the Paratope and Epitope of TNFα Bound to Adalimumab
Educational Materials on Advanced Fox-Based HRPF
Structural Investigation of Therapeutic Antibodies Using Hydroxyl Radical Protein Footprinting Methods paper written by Dr. Corie Ralston of the Lawrence Berkeley National Laboratory and Prof. Joshua Sharp of The University of Mississippi and published in the journal Antibodies.
WHITE PAPER
Revealing Antibody Aggregation with Fox® Protein Footprinting Technology
Understanding protein-protein interactions so researchers can develop high concentration biotherapeutics.
POSTER NOTE
Fox® HRPF System Accurately Maps the Epitope of TNFα Bound to Adalimumab
Learn how Fox-based FPOP detected 4 TNF-α peptides with a significant decrease in oxidation following Ab binding known to be a part of the
TNFα-Ab interface.
TECH NOTE
Review of Technologies for Biopharmaceutical Higher Order Structural (HOS) Analysis
Identifying the most robust and state-of-the-art HOS analytical method for biotherapeutic discovery and development.
SERVICES FAQs
Fox® Protein Footprinting Services for Higher Order Structural (HOS) Analysis
Learn about HRPF services from what can be studied, what data can be generated, what samples are required, to starting a service project with GenNext.
Interview with Dr. Joshua Sharp on Characterizing the HOS of mAbs
Hear about his recent article on the Structural Investigation of Therapeutic Antibodies Using Hydroxyl Radical Protein Footprinting Methods and how GenNext is engineering new technologies to answer difficult HOS questions.
Dr. Joshua Sharp from the University of Mississippi and GenNext Technologies
Dr. Sharp is a world-renowned expert with more than 25 peer-reviewed articles and numerous lectures on biopharmaceutical HRPF. Publishing the first benchtop methods for HRPF, Dr. Sharp’s innovations included the use of UV photolysis of hydrogen peroxide for hydroxyl radical generation. Along with his role as Chief Technology Officer for GenNext, Dr. Sharp is also an Associate Professor of Pharmacology and Research in the Research Institute of Pharmaceutical Sciences at the University of Mississippi. Professor Sharp serves on multiple national and international advisory and review panels as an expert on protein and carbohydrate biophysical and structural analysis by mass spectrometry.