Protein Footprinting Applications in Structural Biology

ABSTRACT

This hour-long seminar, hosted with The Analytical Scientist, reviews structural biology case studies showcasing the successful application of protein footprinting in solving key problems in biopharmaceutical research. Examples include epitope and paratope mapping, protein interactions, receptor-drug interactions, and protein folding/unfolding. The seminar highlights the benefits of using protein footprinting technology in advancing biopharmaceutical research.

SPEAKER

At Washington University in St. Louis, the Gross research group focuses mainly on the development of mass spectrometry (MS) in biophysics and structural proteomics, specifically to probe protein-ligand interaction interfaces, affinities, aggregation, and folding/unfolding. The work includes both instrument and method development and application to important proteins and protein complexes. His research group also employs specific chemical reagents to footprint proteins and determines their interfaces and orientations in complex biological settings, hydrogen/deuterium exchange, and native MS

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