Don’t Miss our 5-Part Protein Footprinting Seminar Series!


GenNext Products & Services

GenNext has pioneered a superior, compact, cost-effective, and safe means of performing HRPF analysis by replacing expensive, complicated, and hazardous lasers with our proprietary Flash Oxidation (FOX™) Protein Footprinting System in a convenient benchtop format.

To address reproducibility challenges, GenNext has developed the FOX Radical Dosimeter — the world’s first OH radical measurement system that automatically controls the generation of effective OH radicals in the face of unpredictable and varying background scavenging. The FOX Dosimeter provides real-time measurement of OH radical concentration, making it simple to detect problems with biopharmaceutical solutions or assay conditions before mass spectrometric analysis is performed, vastly improving HRPF ease of use while simultaneously ensuring labeling confidence and fidelity.

To eradicate present day bioinformatics and data processing bottlenecks, GenNext introduces FoxWare™ Data Processing — a unique data processing program specifically tailored to aptly address and automate data processing demands of HRPF HOS analysis.

Learn how our products can easily fit into your lab’s workflow or test-drive the Fox System on an outsourced project basis.

Flash Oxidation (FOX™) Protein Footprinting System

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FPOP Accessories for
Lab-Built FPOP Systems

For researchers using lab-made FPOP HRPF systems, GenNext offers a variety of accessories to perform real-time monitoring of OH radical generation, as well as supplying modules for the automated collection of labeled product.


On-Demand Presentations

Technologies for Higher
Order Structural Analysis

Helping you choose the method that empowers your lab to develop safe and effective biotherapeutics.


Fox™ Protein Footprinting
for mAb Aggregation

Learn how you can characterize mAb aggregation and determine how excipients help stabilize the protein.


A Novel Laser-Free
FPOP Platform

Overview of HRPF focusing on the fundamentals of the technique and applications in pharmaceutical science.


JoVE On-Line Protocol

Method to perform flash oxidation protein footprinting using inline radical dosimetry and a plasma light source.



The application of Fox™-based HRPF technology in biopharmaceutical discovery and development is always expanding, from drug-binding, mAb therapeutics, and protein aggregation to formulation studies.

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HOS Technology

GenNext sifted through the available HOS analysis options, from low- to high-resolution approaches, to help you determine the most robust, cost-effective, and workflow-friendly approach for your lab.

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Watch recorded presentations, protocols, and interviews with GenNext scientists and our Scientific Advisory Board on Fox™-based HRPF on subjects ranging from applications to methods.

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The Team

The GenNext team is an accomplished collection of scientific, engineering, and commercialization experts who have been creating first-in-class life science tools for both startups and industry giants.

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Learn about Hydroxyl Radical Protein Footprinting technology by reading the growing list of publications authored by GenNext scientists and members of our Scientific Advisory Board.

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NIH Support

Research and Development efforts at GenNext have been graciously supported by NIH Small Business Innovation and Research Awards from the National Institute of General Medical Sciences.

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Meet the GenNext Scientific Advisory Board

Meet Dr. Mark Chance

Meet the world-famous father of HRPF, Dr. Mark Chance. In this interview, he describes being motivated to develop a new technique to see, with much greater resolution, proteins in motion. Living in the “magical middle ground” of moderate cost and higher resolution, Dr. Chance discusses his lab’s use HRPF technology on biological samples to detect the severity of a neurological disease.

Meet Dr. Joshua Sharp

 Watch as Genny the GenNext Fox interviews the world-renowned and internationally recognized expert in Hydroxyl Radical Protein Footprinting (HRPF)—Dr. Joshua Sharp. Inventor of the first benchtop HRPF system and the pioneer of UV photolysis of hydrogen peroxide for hydroxyl radical generation, Josh has a lot of interesting things to say about HRPF.

Request a custom HRPF webinar for your lab.

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Discover the Benefits of HRPF

Accelerate biopharmaceutical and biosimilar development and protein conformational research.

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